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Cho Selected Publications

• Blitz, I.L. and Cho, K.W. (2009). Finding partners: How BMPs select their targets. Dev Dynamics, 13:1321-1331.Blitz and Cho, 2009 (review)

• Ogata, S., Hayata, T., Nihers, C., Morokuma, M., Ueno, N., Cho, K.W.Y. (2007). FLRT3 and Rnd1 are activin-inducible regulators of cadherin-mediated cell adhesion in the vertebrate gastrula. Genes Dev 21:1817-31.

• Yao, L.C., Blitz, I.L., Peiffer, D.A., Phin, S., Wang, Y., Ogata, S., Cho, K.W.Y., Arora, K., and Warrior, R., (2007). Schnurri transcription factors mediate a phylogenetically conserved nuclear response to BMP signaling. Development, 133, 4025-34

• Koide, T, Hayata, T and Cho, K.W.Y. (2006). Negative regulation of hedgehog signaling by cholesterogenic enzyme, 7 hydocholesterol reductase. Development, 133: 2395-2405.

• von Bubnoff, A., Peiffer, D., A., Blitz, I.L., HayataT., Ogata, S., Miyazono, K., and Cho, K.W.Y. (2005). Phylogenetic footprinting and genome scanning identifies vertebrate BMP response elements and new target genes, Dev Biol. 281:210-26.

• Ring, C., Ogata, S., Meek, L., Song, J., Ohta, T., Miyazono, K., and Cho, K.W.Y. (2002) The role of a Williams-beuren syndrom-associcated helix-tloop-helix domain-containing transcription factor in activin/nodal signaling. Genes & Dev. 16:820-835.

• Scott, I.C., Blitz, I.L., Pappano, W.N., Cho,K.W.Y*., Greenspan, D.S.* (2001). Vertebrate twisted gastrulation is a cofactor involved in BMP antagonism. Nature, 411:720-723. (* contributed equally).

• Rothbacher, U., Laurent, M., Deardorff, M.A., Klein, P.S., Cho, K.W.Y*., and Fraser, S.E.* (2000). (* contributed equally). Dishevelled phosphorylation, subcellular localization and homodimerization regulate its role in early emrbyogenesis. The EMBO J. 19:1010-1022.

• Nishita, M., Hashimoto, M, Laurent, M.N., Ueno, N., Shibuya, H, and Cho, K.W.Y. (2000).Direct Physical Interaction of Lef1/Tcf, _-catenin and Smad4 Transcription Factors in Formation of Spemann’ s Organizer. Nature 403: 781-785.

• Wunnenberg-Stapleton, K., Blitz, I.L., Hashimoto, C., and Cho, K.W.Y. (1999). Involvement of the small GTPases XrhoA and XRnd1 in morphogenesis and head formation in early Xenopus development. Development 126:5339-5351.

• Marques, G., Mussachio, M., Wunnenberg-Stapleton, K., Shimell, M.J., Cho, K.W.Y., and O’Connor, M.B. (1997). Production of a Dpp activity gradient in the early Drosophila embryo through the opposing actions of the Sog and Tld proteins. Cell, 91:417-426.

• Laurent, M., Hashimoto, C., Blitz, I.L., Rothbacher, U., Cho, K.W.Y. (1997). The Xenopus homeobox gene Twin mediates Wnt induction of goosecoid in establishment of Spemann’s organizer. Development 124: 4905-4916.

• Watabe, T., Inoue, K., Kim, S., Candia, A., Rothbacher, U., and Cho, K.W.Y. (1995). Establishment of Spemann’s organizer formation: conserved growth factor synergy between Xenopus and mouse. Genes Dev. 9:3038-3050.

• Hawley, S., Wunnenberg-Stapleton, K., Hashimoto, C., Watabe, T., and Cho, K.W.Y. (1995). Disruption of BMP signals in embryonic Xenopus ectoderm leads to direct neural induction. Genes Dev. 2923-2935.

• Blitz. I., and Cho, K.W.Y. (1995). Anterior neuroectoderm is progressively induced during gastrulation: the role of the Xenopus homeobox gene orthodenticle. Development, 121, 993-1004.

• Cho, K.W.Y., Blumberg, B., Steinbeisser, H., and De Robertis, E. (1991) Molecular nature of Spemann’s organizer: the role of the Xenopus homeobox gene goosecoid. Cell 67; 1111-1120.

• Blumberg, B., Wright, C.V.E., De Robertis, E.M., and Cho, K.W.Y. (1991). Organizer- specific homeobox genes from Xenopus laevis embryos. Science 253; 194-196.

Cho Lab Publications (1995-2007)

Blitz. I., and Cho, K.W.Y. (1995). Anterior neuroectoderm is progressively induced during gastrulation: the role of the Xenopus homeobox gene orthodenticle. Development, 121, 993-1004. (blitzdev1995.pdf)

Hawley, S., Wunnenberg-Stapleton, K., Hashimoto, C., Watabe, T., and Cho, K.W.Y. (1995). Disruption of BMP signals in embryonic Xenopus ectoderm leads to direct neural induction. Genes & Development. 2923-2935.

Watabe, T., Inoue, K., Kim, S., Candia, A., Rothbacher, U., and Cho, K.W.Y. (1995). Establishment of Spemann’s organizer formation: conserved growth factor synergy between Xenopus and mouse. Genes & Development. 9:3038-3050.

Hashimoto, C., and Cho, K.W.Y. (1996). Neural induction (review) Experimental Medicine, 14:102.-106.

Artinger, M., Inoue, K., Tran, U, and Cho, K.W.Y. (1997). Interaction of goosecoid and Brachyury in Xenopus mesoderm patterning. Mechanisms of Development. 65: 187-196.

Candia, A.F., Watabe, T., Hawley S.H., Onichtchouk, D., Zhang, Y., Derynck, R., Niehrs, C., and Cho, K.W.Y. (1997). Cellular interpretation of multiple TGF-b signals: Intracellular antagonism of activin/BVg1 and BMP2/4 signaling mediated by Smads. Development 124:4467-4480. (candiadev1997.pdf)

Laurent, M., Hashimoto, C., Blitz, I.L., Rothbacher, U., Cho, K.W.Y. (1997). The Xenopus homeobox gene Twin mediates Wnt induction of goosecoid in establishment of Spemann�s organizer. Development 124: 4905-4916. (laurentdev1997.pdf)

Marques, G., Mussachio, M., Wunnenberg-Stapleton, K., Shimell, M.J., Cho, K.W.Y., and O�Connor, M.B. (1997). Production of a Dpp activity gradient in the early Drosophila embryo through the opposing actions of the Sog and Tld proteins. Cell, 91:417-426. (marquescell1997.pdf)

Watabe, T., Candia, A., and Cho, K.W.Y. (1997). Activin signaling pathways and their role in Xenopus mesoderm formation. (book chapter). �Inhibitin, activin and follistatin�. Serano Symposium. Springer-Verlag, NY.

Beatriz Ferreiro, Michael Artinger, Ken W.Y. Cho, and Christof Niehrs. (1998) Antimorphic goosecoid. Development .125, 1347-1359. (gscdev1998.pdf)

Cho, K.W.Y. and Blitz, I. (1998). Extracellular and intracellular mode of BMP signaling. Current Opinions in Genetics and Development.8:443-449

Laurent, M.N., and Cho, K.W.Y. (1999). Bone morphogentic protein antagonism of Spemann�s organizer is independent of Wnt signaling. Developmental Biology. 206:157-162. (laurentdb1999.pdf)

Ring, C and Cho, K.W.Y. (1999). Insights from Model Organisms: Specificity in transforming growth factor-b signaling pathways. Am.J. Hum. Genet 64.

Wunnenberg-Stapleton, K., Blitz, I.L., Hashimoto, C., and Cho, K.W.Y. (1999). Involvement of the small GTPases XrhoA and XRnd1 in morphogenesis and head formation in early Xenopus development. Development. Dec;126 (23):5339-51. (wunnenbergdev1999.pdf)

Scott, I.C., Blitz, I.L., Pappano, W.N., Imamura, Y., Clark, T.C., Steiglitz, B.M., Thomas, C.L., Maas, S.A., Cho, K.W.Y., and Greenspan, D.S. (1999). Mammalian BMP-1/Tolloid-related metalloproteinases, including novel family member mammalian Tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis.. Developmental Biology. 213:283-300. (scottdb1999.pdf)

Cho, K.W.Y. Mesoderm Induction (review) Experimental Medicine (1999).

Blitz, I.L., Shimmi, O., Wunnenberg-Stapleton, K., O�Connor, M.B., & Cho, K.W.Y. (2000). Is chordin a long-range- or short-range-acting factor? Roles for BMP1-related metalloproteases in chordin and BMP4 autofeedback loop regulation. Developmental Biology. 223, 120-138. (blitzdb2000.pdf)

Nishita M, Hashimoto MK, Ogata S, Laurent MN, Ueno N, Shibuya H, Cho KW (2000). Interaaction between Wnt and TGF-B signaling pathways during formation of Spemanns organizer. Nature. 403, 781-785. (Nature403.pdf)

Rothbacher, U., Laurent, M., Deardorff, M.A., Klein, P.S., Cho, K.W.Y., and Fraser, S.E. (2000). Dishevelled phosphorylation, subcellular localization and homodimerization regulate its role in early emrbyogenesis. The EMBO Journal.19:1010-1022. (dishevelledEMBO2001.pdf)

Karavanov, A., Mochizuki, T., Curtiss, P.E., Ault, K.T., Sugimoto, N., Watabe, T., Shiokawa, K, Jamrich, M., Cho, K.W.Y., Dawid, I.B., and Taira, M. (2000). Xlim-1 and LIM domain binding protein 1 cooperate with other transcription factors in the regulation of the goosecoid promoter. Developmental Biology. 224: 470-485. (mochizukietal2000.pdf)

Scott, I.C., Blitz, I.L., Pappano, W.N., Cho,K.W.Y., Greenspan, D.S. (2001) Homologues of Twisted gastrulation are extracellular cofactors in antagonism of BMP signalling., Nature. Mar 22; 10(6827): 475-8. (scott&blitz2001.pdf)

Von bubnoff A, Cho KW. (2001). Intracellular BMP signaling regulation in vertebrates: pathway or network? Developmental Biology. Nov 1;239(1):1-14. (vonbubnoff&cho2001.pdf)

Ring C, Ogata S, Meek L, Song J, Ohta T, Miyazono K, Cho KW (2002). The role of a Williams-Beuren syndrome-associated helix-loop-helix domain-containing transcription factor in activin/nodal signaling. Genes & Development. Apr 1;16(7):820-35. (wbs.pdf)

Tran, P.H., Peiffer, D. A., Shin, Y., Meek, L.M., Brody, J.P., Cho, K.W., (2002) Microarray Optimizations: Increasing Spot Accuracy and Automated Identification of True Microarray Signals. Nucleic Acids Research. Jun 15;30(12):e54. (microarray1.pdf)

Hashimoto-Partyka MK, Yuge M, Cho KW. Nodal signaling in Xenopus gastrulae is cell-autonomous and patterned by beta-catenin. (2003) Developmental Biology. Jan 1;253(1):125-38. (minakodb2001.pdf)

Yoshida Y, von Bubnoff A, Ikematsu N, Blitz IL, Tsuzuku JK, Yoshida EH, Umemori H, Miyazono K, Yamamoto T, Cho KW. (2003) Tob proteins enhance inhibitory Smad-receptor interactions to repress BMP signaling. Mechanisms of Development. 120 (5):629-37. (yoshidamod2003.pdf)

Tsuji S, Cho KW, Hashimoto C. Expression pattern of a basic helix-loop-helix transcription factor Xhairy2b during Xenopus laevis development. (2003) Development, Genes, and Evololution. 213(8):407-11. (tsujidevgenesevol2003.pdf)

Blitz, I., Cho, KW., Chang, C. (2003). Twisted gastrulation loss-of-function analyses support its role as a BMP inhibitor during early Xenopus embryogenesis. Development. 130:4975-4988. (tsgdev2003.pdf)

Peiffer, D. A., Cho, K. W. Y., Shin, Y. (2003). Xenopus DNA Microarrays. Current Genomics. Vol. 4, no. 8, pp. 665-672(8). (CG-Peiffer.pdf)

Meek L.M., Hayata T, Shin Y.C., Evinger A.J., Cho K.W.Y. Cloning and expression of an SH3 domain-containing protein (Xchef-1), a novel downstream target of activin/nodal signaling. (2004) Gene Expr Patterns. Oct;4(6):719-24. (Meek.pdf)

Blitz, I., and Cho, K.W.Y. (2004) Short versus long range effects of Spemanns Organizer. In The Veterbrate Organizer. Heidelberg: Springer Press. (ShortversusLong.pdf)

Shin, Y., Kitayama, A., Koide, T., Peiffer, D.A., Mochii, M., Liao, A., Ueno, K., Cho, K.W.Y. (2005). Identification of neural genes using Xenopus DNA microarrays. Developmental Dynamics. (232):432-444. (Shinmicroarray.pdf)

Peiffer, D.A., von Bubnoff, A., Shin, Y., Mochii, M., Ueno, N., and Cho, K.W.Y. (2005) A Xenopus laevis DNA microarray approach to identify novel direct BMP target genes in early embryonic development. Developmental Dynamics. (232):445-456. (Peiffermicroarray.pdf)

Arima K, Shiotsugu J, Niu R, Khandpur R, Martinez M, Shin Y, Koide T, Cho KW, Kitayama A, Ueno N, Chandraratna RA, Blumberg B. (2005) Global analysis of RAR-responsive genes in the Xenopus neurula using cDNA microarrays. Developmental Dynamics. 232(2):414-31. (arima2004.pdf)

Koide T, Hayata T, Cho KW. (2005) Gene Regulatory Networks Special Feature: Xenopus as a model system to study transcriptional regulatory networks. Proc Natl Acad Sci USA. 102(14):4943-8 (KoidePNAS.pdf)

Baldessari D, Shin Y, Krebs O, Konig R, Koide T, Vinayagam A, Fenger U, Mochii M, Terasaka C, Kitayama A, Peiffer D, Ueno N, Eils R, Cho KW, Niehrs C. (2005) Global gene expression profiling and cluster analysis in Xenopus laevis. Mechanisms of Development. 22(3):441-75 (BaldessariMOD.pdf)

Taverner NV, Kofron M, Shin Y, Kabitschke C, Gilchrist MJ, Wylie C, Cho KW, Heasman J, Smith JC. (2005) Microarray-based identification of VegT targets in Xenopus. Mechanisms of Development. 122(3):333-54 (VegTMOD.pdf)

von Bubnoff, A., Peiffer, D.A., Blitz, I.L. Hayata, T., Ogata, S., Zeng, q., Trunnell, M., Cho, K.W.Y. (2005) Phylogenetic footprinting and genome scanning identify vertebrate BMP response elements and new target genes. Dev Biol. 281:210-26.von Bubnoff et al., 2005

Luo, T., Zhang, Y., Khadka, D., Rangarajan, J., Cho, K.W. Y, and Sargent, T.D. (2005) Regulatory targets for transcription factor AP2 in Xenopus embryos. Dev Growth & Differentiation. 47:403-13.luo-et-al-2006.pdf

Yamaguti M, Cho KW, Hashimoto C. (2005). Xenopus hairy2b specifies anterior prechordal mesoderm identity within Spemann’s organizer. Dev Dynamics 234:102-13.yamaguchi-et-al-hairy-2005.pdf

Murato, Y., Yamaguti, M., Katamura, M., Cho, K.W.Y. and Hashimoto, C.(2006) Two modes of action by which Xenopus Hairy2b establishes tissue demarcation in Spemann’s organizer. Int. J. Dev. Biol. 50: 463-471.muratoijdb2006.pdf

Koide, T, Hayata, T and Cho, K.W.Y. (2006). Negative regulation of hedgehog signaling by cholesterogenic enzyme, 7 hydocholesterol reductase. Development, 133: 2395-2405.koide-et-al-dhcr7_2006.pdf

Chalmers, A.D., Lachani, K., Shin, Y., Sherwood, V., Cho, K.W.Y., papalopulu, N. (2006). Grainyhead-like 3, a transcription factor identified in a microarray screen, promotes the specification of the superficial layer of the embryonic epidermis. Mech Dev, 123:702-718. et al., 2005

Li, S., Shin, Y., Cho, K.W.Y., and Merzdorf, C.S., (2006). The Xfeb gene is directly upregulated by Zic1 during early neural development. Dev Dynamics. 285: 2817-2827.limerzdorf-2006.pdf

Yao, L.C., Blitz, I.L., Peiffer, D.A., Phin, S., Wang, Y., Ogata, S., Cho, K.W.Y., Arora, K., and Warrior, R., Schnurri transcription factors mediate a phylogenetically conserved nuclear response to BMP signaling. Development, 133, 4025-34.yao-et-al-2006.pdf

Koide, T., Hayata, T., and Cho, K.W.Y. (2006). More challenges ahead of DHCR’s role in Hh signaling. Correspondence in Development, 133:3952-3.koide-et-al-dhcr7_2006.pdf

Suzawa K, Yukita A, Hayata T, Goto T, Danno H, Michiue T, Cho KW, Asashima M. (2007). Xenopus glucose transporter 1 (xGLUT1) is required for gastrulation movement in Xenopus laevis. Int J Dev Biol. 51:183-90. Suzawa et al., 2007

Changkyun Park E, Hayata T, Cho KW, Han JK. (2007). Xenopus cDNA microarray identification of genes with endodermal organ expression. Dev Dyn. 236:1633-49.park-et-al-2007.pdf

Ogata, S., Hayata, T., Nihers, C., Morokuma, M., Ueno, N., Cho, K.W.Y. (2007). FLRT3 and Rnd1 are activin-inducible regulators of cadherin-mediated cell adhesion in the vertebrate gastrula. Genes Dev. 21:1817-31. Ogata et al., 2007

Cho, K.W., and Hayata, T. (2007). Finding gene expression changes using microarray technology. (book chapter for Principal of Developmental Genetics, edited by Sally Moody).

Maretto S, Müller PS, Aricescu AR, Cho KW, Bikoff EK, Robertson EJ. (2008). Ventral closure, headfold fusion and definitive endoderm migration defects in mouse embryos lacking the fibronectin leucine-rich transmembrane protein FLRT3. Dev Biol. 318:184-93.

Hayata T, Blitz IL, Iwata N, Cho KW. (2009). Identification of embryonic pancreatic genes using Xenopus DNA microarrays. Dev Dyn.238:1455-1466.Hayata et al., 2009

Jarikji, Z., Horb, LZ., Shariff1, F., Mandato, C.A., Cho, KW, and Horb, M.E. (2009). The tetraspanin tm4sf3 is localized to the ventral pancreas and regulates fusion of the dorsal and ventral pancreatic buds. Development, 136:1791-1800. Jarikji et al., 2009

Blitz, I.L. and Cho, K.W. (2009). Finding partners: How BMPs select their targets. Dev Dynamics, 13:1321-1331.Blitz and Cho, 2009 (review)

Karaulanov, E., Böttcher, R.T., Stannek, P., Wu, W., Rau, M., Ogata, S., Cho, K.W. and Niehrs, C. (2009). Unc5B interacts with FLRT3 and Rnd1 to modulate cell adhesion in Xenopus embryos. Dev Dynamics, in press.

Last update 2.28.2007